Hemodialyzer Reuse and Gram-Negative Bloodstream Infections

Procalcitonin Levels in Gram-Positive, Gram-Negative, and Fungal Bloodstream Infections

Procalcitonin (PCT) can discriminate bacterial from viral systemic infections and true bacteremia from contaminated blood cultures. The aim of this study was to evaluate PCT diagnostic accuracy in discriminating Gram-positive, Gram-negative, and fungal bloodstream infections. A total of 1,949 samples from patients with suspected bloodstream infections were included in the study. Median PCT valu...

Seasonal and Temperature-Associated Increases in Gram-Negative Bacterial Bloodstream Infections among Hospitalized Patients

BACKGROUND Knowledge of seasonal trends in hospital-associated infection incidence may improve surveillance and help guide the design and evaluation of infection prevention interventions. We estimated seasonal variation in the frequencies of inpatient bloodstream infections (BSIs) caused by common bacterial pathogens and examined associations of monthly BSI frequencies with ambient outdoor temp...

Gram-Negative Polymicrobial Bloodstream Infections and Clinical Decision Making with a Microarray Testing System

Emerging gram-negative enteric infections.

This is an overview describing the microbiology, epidemiology, clinical presentations, laboratory diagnosis, and treatment of emerging gram-negative enteric infections. This review illustrates the shifts in epidemiology of infections caused by new and reemerging bacteria and highlights the role of the clinical microbiology laboratory in detecting these pathogens. It concludes with suggestions f...

Antibiotics for Gram-negative infections

We do need them, and we need them now! New antibacterial drugs have been developed on the last 2 years for Grampositive agents,(1) but not with new targets. There has been real progress in developing antimycobacterial agents, including some new modes of action;(2) however, what we have available today for Gramnegative multiresistant bacteria is the same we had 5 years ago, except for some molec...